Chapter 7

Chapter 7: Discrete dynamic models: Boolean networks #

  1. Consider the following reaction sequence and choose the correct statement(s) about the essentiality of the genes, g1, g2 and g3.
R1: A + B → C        g1 OR g2
R2: C + A  → D       g2 OR g3
R3: B + D  → E + F   g1 AND g2
R4: A + D  → E + F   g1 AND g2
R5: E + F  → Biomass

        a. g1 is non-essential
        b. g2 is non-essential
        c. g3 is non-essential
        d. g1, g2 and g3 are all essentials
        Ans: c

  1. The following figure shows a simple gene regulatory network. Normal arrowheads on the edges indicate activation and circle-headed blue arrows indicate inhibition/repression. Check the correct Boolean transfer function(s). Gene

        a. g1* = g4 AND (NOT g2)
        b. g2* = g1 AND (NOT g3)
        c. g3* = NOT g4
        d. g2* = g3 AND (NOT g1)

        Ans: a, b