Chapter 13: Robustness and evolvability of biological systems #
Biological Robustness
Kitano (2004) Nature Reviews GeneticsA classic review of concepts of biological robustness.
Bow ties, metabolism and disease
Csete and Doyle (2004) Trends in BiotechnologyA nice discussion of bow ties in biological systems.
Complexity and Robustness
Carlson and Doyle (2002) Proceedings of the National Academy of Sciences USAA detailed piece on highly optimised tolerance.
Evolution of Bow-Tie Architectures in Biology
Friedlander et al. (2005) PLoS Computational BiologyA very interesting paper, showing how bow-ties can evolve spontaneously under certain conditions/constraints.
Neutralism and selectionism: a network-based reconciliation
Wagner (2008) Nature Reviews GeneticsA wonderful treatise on neutralism vs. selectionism, from a ‘neutral’ network perspective.
Innovation and robustness in complex regulatory gene networks
Ciliberti et al. (2007) Proceedings of the National Academy of Sciences USARobustness, evolvability and innovation, as studied in a gene regulatory network system.
Robustness and evolvability: a paradox resolved
Wagner (2008) Proceedings of the Royal Society B: Biological SciencesThe classic paper, beautifully reconciling the seemingly paradoxical relationship between robustness and evolvability.
Andreas Wagner interview (Zürich Minds)
An interview of Andreas Wagner, discussing robustness, evolvability, and innovation.