Chapter 12

Chapter 12: Designing biological circuits #

Introduction to Synthetic Biology

A fun over-simplified introduction to synthetic biology, paralleling it with computers.

Synthetic Biology, Inventing the Future by Andrew Hessel

A nice interview of Andrew Hessel, on synthetic biology.

Synthetic Biology: Honors Colloquium by JJ Collins

An excellent talk by JJ Collins, one of the most renowned scientists in synthetic biology.

Realizing the potential of synthetic biology
Church et al. (interview) (2014) Nature Reviews Molecular Cell Biology

A nice interview-type article on synthetic biology.

Foundations for engineering biology
Endy (2005) Nature

A nice engaging review of synthetic biology.

Genome-scale engineering for systems and synthetic biology
Esvelt and Wang (2013) Molecular systems biology

An excellent review of technologies and methodologies for genome editing in synthetic biology.

The second wave of synthetic biology: from modules to systems
Purnick and Weiss (2009) Nature Reviews Molecular Cell Biology

A nice overview of multiple synthetic biology circuits.

Synthetic biology: applications come of age
Khalil and Collins (2010) Nature Reviews Genetics

A nice overview of a large number of applications of synthetic biology, from drug synthesis to biofuels to therapies.

The art of molecular computing: Whence and whither
Gangadharan and Raman (2021) BioEssays

A detailed review of DNA computing, highlighting key experiments across three different eras of molecular computation, beginning with molecular solutions, transitioning to logic circuits and ultimately, more complex molecular networks.