Synthetic Lethals

publications

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Understanding flux switching in metabolic networks through an analysis of synthetic lethals

Sowmya Manojna Narasimha†, Tanisha Malpani†, Omkar S. Mohite, J. Saketha Nath, Karthik Raman*,

npj Systems Biology and Applications

10:104
10.1038/s41540-024-00426-5
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Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma

Swagatika Sahoo*, Ranjith Kumar R, Brandon Nicolay, Omkar Mohite, Karthikeyan Sivaraman, Vikas Khetan, Pukhraj Rishi, Suganeswari Ganesan, Subramanian Krishnakumar, Karthik Raman, Wayne Miles, Sailaja V Elchuri*,

FEBS Letters

593:23-41
10.1002/1873-3468.13294
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Understanding the evolution of functional redundancy in metabolic networks

Gayathri Sambamoorthy, Karthik Raman*,

Bioinformatics

34:i981-i987
10.1093/bioinformatics/bty604
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Computational Prediction of Synthetic Lethals in Genome-Scale Metabolic Models Using Fast-SL

Karthik Raman*, Aditya Pratapa, Omkar Mohite, Shankar Balachandran,

Methods Mol Biol

1716:315-336
10.1007/978-1-4939-7528-0_14
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Fast-SL: An efficient algorithm to identify synthetic lethal sets in metabolic networks

Aditya Pratapa, Shankar Balachandran, Karthik Raman*,,

Bioinformatics

31:3299-3305
10.1093/bioinformatics/btv352