Metabolic Networks

publications

Understanding flux switching in metabolic networks through an analysis of synthetic lethals

Sowmya Manojna Narasimha†, Tanisha Malpani†, Omkar S. Mohite, J. Saketha Nath, Karthik Raman*,

npj Systems Biology and Applications

10:104

10.1038/s41540-024-00426-5

Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station

Pratyay Sengupta, Shobhan Karthick Muthamilselvi Sivabalan, Nitin Kumar Singh, Karthik Raman*, Kasthuri Venkateswaran*,

Microbiome

12:62

10.1186/s40168-024-01777-1

Genome-scale metabolic model led engineering of Nothapodytes nimmoniana plant cells for high camptothecin production

Sarayu Murali, Maziya Ibrahim, Hemalatha Rajendran, Shagun Shagun, Shyam Kumar Masakapalli, Karthik Raman, Smita Srivastava*,

Frontiers in Plant Science

14:1207218

10.3389/fpls.2023.1207218

Metabolic modeling of the International Space Station microbiome reveals key microbial interactions

Rachita K Kumar, Nitin Singh, Sanjaay Balakrishnan, Ceth W. Parker, Karthik Raman*, Kasthuri Venkateswaran*,

Microbiome

10:102

10.1186/s40168-022-01279-y

A Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites

Lavanya Raajaraam, Karthik Raman*,

Frontiers in Bioengineering and Biotechnology

9:779405

10.3389/fbioe.2021.779405

Two-species community design of lactic acid bacteria for optimal production of lactate

Maziya Ibrahim, Karthik Raman*,

Computational and Structural Biotechnology Journal

19:6039-6049

10.1016/j.csbj.2021.11.009

Modelling microbial communities: Harnessing consortia for biotechnological applications

Maziya Ibrahim†, Lavanya Raajaraam†, Karthik Raman*,

Computational and Structural Biotechnology Journal

19:3892-3907

10.1016/j.csbj.2021.06.048

Metagenome-Wide Association Analysis Identifies Microbial Determinants of Post-Antibiotic Ecological Recovery in the Gut

Kern Rei Chng, Tarini Shankar Ghosh, Yi Han Tan, Tannistha Nandi, Ivor Russel Lee, Amanda Hui Qi Ng, Chenhao Li, Aarthi Ravikrishnan, Kar Mun Lim, David Lye, Timothy Barkham, Karthik Raman, & more

Nature Ecology and Evolution

4:1256-1267

10.1038/s41559-020-1236-0

MinReact: a systematic approach for identifying minimal metabolic networks

Gayathri Sambamoorthy, Karthik Raman*,

Bioinformatics

36:4309-4315

10.1093/bioinformatics/btaa497

Investigating metabolic interactions in a microbial co-culture through integrated modelling and experiments

Aarthi Ravikrishnan, Lars M. Blank, Smita Srivastava, Karthik Raman,

Computational and Structural Biotechnology Journal

18:1249-1258

10.1016/j.csbj.2020.03.019

Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models

Devika N T, Karthik Raman*,

Scientific Reports

9:18222

10.1038/s41598-019-54696-9

Rational engineering of vitamin E metabolism for enhanced alpha-tocopherol production in Helianthus annuus cell culture

Aparajitha Srinivasan, Vijayakumar S, Karthik Raman, Smita Srivastava*,

Biochemical Engineering Journal

151:107256

10.1016/j.bej.2019.107256

Uncovering Novel Pathways for Enhancing Hyaluronan Synthesis in Recombinant Lactococcus lactis: Genome-Scale Metabolic Modeling and Experimental Validation

Abinaya Badri, Karthik Raman*, Guhan Jayaraman*,

Processes

7:343

10.3390/pr7060343

Evolutionary design principles in metabolism

Gayathri Sambamoorthy, Himanshu Sinha*, Karthik Raman*,

Proc Biol Sci

286:20190098

10.1098/rspb.2019.0098

Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma

Swagatika Sahoo*, Ranjith Kumar R, Brandon Nicolay, Omkar Mohite, Karthikeyan Sivaraman, Vikas Khetan, Pukhraj Rishi, Suganeswari Ganesan, Subramanian Krishnakumar, Karthik Raman, Wayne Miles, Sailaja V Elchuri*,