Computational Systems Biology Lab

Understanding flux switching in metabolic networks through an analysis of synthetic lethals

Sowmya Manojna Narasimha†, Tanisha Malpani†, Omkar S. Mohite, J. Saketha Nath, Karthik Raman*,

npj Systems Biology and Applications

10:104

Designing function-specific minimal microbiomes from large microbial communities

Aswathy Raghu, Indumathi Palanikumar, Karthik Raman*,

npj Systems Biology and Applications

10:46

Genome-scale metabolic model led engineering of Nothapodytes nimmoniana plant cells for high camptothecin production

Sarayu Murali, Maziya Ibrahim, Hemalatha Rajendran, Shagun Shagun, Shyam Kumar Masakapalli, Karthik Raman, Smita Srivastava*,

Frontiers in Plant Science

14:1207218

A Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites

Lavanya Raajaraam, Karthik Raman*,

Frontiers in Bioengineering and Biotechnology

9:779405

Two-species community design of lactic acid bacteria for optimal production of lactate

Maziya Ibrahim, Karthik Raman*,

Computational and Structural Biotechnology Journal

19:6039-6049

MinReact: a systematic approach for identifying minimal metabolic networks

Gayathri Sambamoorthy, Karthik Raman*,

Bioinformatics

36:4309-4315

Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models

Devika N T, Karthik Raman*,

Scientific Reports

9:18222

Rational engineering of vitamin E metabolism for enhanced alpha-tocopherol production in Helianthus annuus cell culture

Aparajitha Srinivasan, Vijayakumar S, Karthik Raman, Smita Srivastava*,

Biochemical Engineering Journal

151:107256

Uncovering Novel Pathways for Enhancing Hyaluronan Synthesis in Recombinant Lactococcus lactis: Genome-Scale Metabolic Modeling and Experimental Validation

Abinaya Badri, Karthik Raman*, Guhan Jayaraman*,

Processes

7:343

Fast-SL: An efficient algorithm to identify synthetic lethal sets in metabolic networks

Aditya Pratapa, Shankar Balachandran, Karthik Raman*,,

Bioinformatics

31:3299-3305

Critical assessment of genome-scale metabolic networks: the need for a unified standard

Aarthi Ravikrishnan, Karthik Raman*,

Briefings in Bioinformatics

16:1057-1068

Strategies for efficient disruption of metabolism in Mycobacterium tuberculosis from network analysis

Karthik Raman, Rohit Vashisht, Nagasuma Chandra,

Molecular BioSystems

5:1740-1751

Flux balance analysis of biological systems: applications and challenges

Karthik Raman, Nagasuma Chandra,

Briefings in Bioinformatics

10:435-449

targetTB: A target identification pipeline for Mycobacterium tuberculosis

Karthik Raman, Yeturu Kalidas, Nagasuma Chandra,

BMC Systems Biology

2:109

Flux Balance Analysis of Mycobacterium tuberculosis: targets for anti-tubercular drugs

Karthik Raman, Preethi Rajagopalan, Nagasuma Chandra,

PLoS Computational Biology

1:e46