Computational Systems Biology Lab
Karthik Raman's Lab @ IIT Madras
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Karthik Raman*
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Metagenomic profiling of municipal drinking water microbiomes in an Indian city: Insights into diversity, water quality, and AMR potential
PURE: Policy-guided Unbiased REpresentations for structure-constrained molecular generation
Harnessing machine learning for metagenomic data analysis: trends and applications
An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in *Candida albicans* during host infection
COSMOS: COmmunity and Single Microbe Optimisation System
GViNC: an innovative framework for genome graph comparison reveals hidden patterns in the genetic diversity of human populations
Integrating Model-Informed Drug Development With AI: A Synergistic Approach to Accelerating Pharmaceutical Innovation
Neobacillus driksii sp. nov. isolated from a Mars 2020 spacecraft assembly facility and genomic potential for lasso peptide production in Neobacillus
Understanding flux switching in metabolic networks through an analysis of synthetic lethals
Modeling Microbial Communities: Perspective and Challenges
Panera: A novel framework for surmounting uncertainty in microbial community modelling using Pan-genera metabolic models
Design Principles for Perfect Adaptation in Biological Networks with Nonlinear Dynamics
Designing function-specific minimal microbiomes from large microbial communities
Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station
Design Principles for Biological Adaptation: A Systems and Control-Theoretic Treatment
Metagenome-based metabolic modelling predicts unique microbial interactions in deep-sea hydrothermal plume microbiomes
COWAVE: A Labelled COVID-19 Wave Dataset for Building Predictive Models
Big Data for a Small World: A Review on Databases and Resources for Studying Microbiomes
Sloppiness: fundamental study, new formalism and its application in model assessment
On biological networks capable of robust adaptation in the presence of uncertainties: A linear systems-theoretic approach
Bayesian Optimal Experiment Design for Sloppy Systems
Probing patterning in microbial consortia with a cellular automaton for spatial organisation
iCOMIC: a graphical interface-driven bioinformatics pipeline for analyzing cancer omics data
Discovering design principles for biological functionalities: perspectives from systems biology
Metabolic modeling of the International Space Station microbiome reveals key microbial interactions
Multi-omic data improve prediction of personalized tumor suppressors and oncogenes
Designing Biological Circuits: From Principles to Applications
Discovering adaptation-capable biological network structures using control-theoretic approaches
Novel ratio-metric features enable the identification of new driver genes across cancer types
A Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites
Two-species community design of lactic acid bacteria for optimal production of lactate
NetGenes: A Database of Essential Genes Predicted Using Features From Interaction Networks
Modelling microbial communities: Harnessing consortia for biotechnological applications
The art of molecular computing: whence and whither
Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes
Systems-Theoretic Approaches to Design Biological Networks with Desired Functionalities
MinReact: a systematic approach for identifying minimal metabolic networks
Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models
Uncovering Novel Pathways for Enhancing Hyaluronan Synthesis in Recombinant Lactococcus lactis: Genome-Scale Metabolic Modeling and Experimental Validation
Evolutionary design principles in metabolism
Network-based features enable prediction of essential genes across diverse organisms
Enumerating all possible biosynthetic pathways from metabolic networks
Understanding the evolution of functional redundancy in metabolic networks
Computational Prediction of Synthetic Lethals in Genome-Scale Metabolic Models Using Fast-SL
Predicting Novel Metabolic Pathways through Subgraph Mining
Elucidating the biosynthetic pathways of volatile organic compounds in Mycobacterium tuberculosis through a computational approach
In Silico Approaches to Metabolic Engineering
Critical assessment of genome-scale metabolic networks: the need for a unified standard
Revisiting Robustness and Evolvability: Evolution in Weighted Genotype Spaces
The organisational structure of protein networks: revisiting the centrality--lethality hypothesis
Construction and analysis of protein--protein interaction networks